Assay Detail
Functional
CHEMBL4201267
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Antiproliferative activity against human NCI/ADR-RES cells after 6 days by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.79 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.02 |
| CHEMBL4211567 | — | — | 1 | 5.60 |
| CHEMBL364713 | NOSCAPINE | 2.0 | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4211567 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL364713 | NOSCAPINE | IC50 | = | 17400.0 | nM | 4.76 |