Assay Detail
Binding
CHEMBL4201400
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rabbit PAF receptor assessed as inhibition of PAF-induced platelet aggregation incubated for 5 mins followed by PAF addition
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tetrahydrobenzofuran-6(2 H)-one Neolignans from Ocotea heterochroma: Their Platelet Activating Factor (PAF) Antagonistic Activity and in Silico Insights into the PAF Receptor Binding Mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.37 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296958 | KADSURENONE | — | 1 | 6.82 |
| CHEMBL4206081 | — | — | 1 | 6.64 |
| CHEMBL4210962 | — | — | 1 | 6.41 |
| CHEMBL514432 | GINKOLIDE B | — | 1 | 6.03 |
| CHEMBL561053 | CINERIN C | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296958 | KADSURENONE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4206081 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4210962 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL514432 | GINKOLIDE B | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL561053 | CINERIN C | IC50 | = | 1090.0 | nM | 5.96 |