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Assay Detail

CHEMBL4201411

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of Plasmodium falciparum 3D7 asynchronous cultures by PicoGreen dye based assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.
Wang X, Edwards RL, Ball H, Johnson C, Haymond A, Girma M, Manikkam M, Brothers RC, McKay KT, Arnett SD, Osbourn DM, Alvarez S, Boshoff HI, Meyers MJ, Couch RD, Odom John AR, Dowd CS.
J Med Chem (2018) 61 : 8847 -8858
PubMed 30192536 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.84 7.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL269671 ARTEMISININ 3.0 1 7.98
CHEMBL4206225 1 7.89
CHEMBL3103258 1 7.75
CHEMBL4207168 1 7.72
CHEMBL3103256 1 6.70
CHEMBL1922604 1 6.29
CHEMBL2164257 FOSMIDOMYCIN SODIUM 1 5.96
CHEMBL4215008 1 5.96
CHEMBL4210088 1 5.92
CHEMBL4202817 1 5.64
CHEMBL4213680 1 4.84
CHEMBL4208741 1 4.62
CHEMBL4214479 1 4.58
CHEMBL4211531 1 4.54
CHEMBL4204916 1 4.36
CHEMBL4213140 1 4.30
CHEMBL4213308 1 4.26
CHEMBL4206644 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL269671 ARTEMISININ IC50 = 10.4 nM 7.98
CHEMBL4206225 IC50 = 13.0 nM 7.89
CHEMBL3103258 IC50 = 18.0 nM 7.75
CHEMBL4207168 IC50 = 19.0 nM 7.72
CHEMBL3103256 IC50 = 202.0 nM 6.70
CHEMBL1922604 IC50 = 511.0 nM 6.29
CHEMBL2164257 FOSMIDOMYCIN SODIUM IC50 = 1087.0 nM 5.96
CHEMBL4215008 IC50 = 1100.0 nM 5.96
CHEMBL4210088 IC50 = 1200.0 nM 5.92
CHEMBL4202817 IC50 = 2300.0 nM 5.64
CHEMBL4213680 IC50 = 14300.0 nM 4.84
CHEMBL4208741 IC50 = 23700.0 nM 4.62
CHEMBL4214479 IC50 = 26100.0 nM 4.58
CHEMBL4211531 IC50 = 28600.0 nM 4.54
CHEMBL4204916 IC50 = 44100.0 nM 4.36
CHEMBL4213140 IC50 = 50500.0 nM 4.30
CHEMBL4213308 IC50 = 55200.0 nM 4.26
CHEMBL4206644 IC50 = 113300.0 nM -