Assay Detail
Binding
CHEMBL4201438
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Inhibition of MERS-CoV spike protein-mediated cell-cell fusion in 293T/MERS/EGPF cells assessed as reduction in cell fusion incubated for 4 hrs by inverted fluorescence microscopy
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Middle East respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.03 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216498 | — | — | 1 | 7.00 |
| CHEMBL4206744 | — | — | 1 | 6.96 |
| CHEMBL4127413 | — | — | 1 | 6.82 |
| CHEMBL4204822 | — | — | 1 | 6.62 |
| CHEMBL4215944 | — | — | 1 | 6.35 |
| CHEMBL4209173 | — | — | 1 | 6.28 |
| CHEMBL4211627 | — | — | 1 | 5.78 |
| CHEMBL4204274 | — | — | 1 | 5.53 |
| CHEMBL4217029 | — | — | 1 | 5.51 |
| CHEMBL4212602 | — | — | 1 | 5.35 |
| CHEMBL4212054 | — | — | 1 | 5.20 |
| CHEMBL4204307 | — | — | 1 | 4.97 |
| CHEMBL4207695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216498 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4206744 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4127413 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4204822 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4215944 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4209173 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4211627 | — | EC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4204274 | — | EC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL4217029 | — | EC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL4212602 | — | EC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL4212054 | — | EC50 | = | 6260.0 | nM | 5.20 |
| CHEMBL4204307 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4207695 | — | EC50 | > | 10000.0 | nM | - |