Assay Detail
Functional
CHEMBL4201440
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Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in HEK293T cells assessed as inhibition of viral replicon activity incubated for 30 hrs by dual-Glo luciferase assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.70 | 5.83 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 5.83 |
| CHEMBL4206744 | — | — | 1 | 5.76 |
| CHEMBL4216498 | — | — | 1 | 5.71 |
| CHEMBL4209173 | — | — | 1 | 5.50 |
| CHEMBL4212017 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | EC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4206744 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4216498 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4209173 | — | EC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL4212017 | — | Inhibition | - | % | - |