Assay Detail
Binding
CHEMBL4201511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BTN3A1 in human PBMC assessed as stimulation of Vgamma9 Vdelta2 T cells incubated for 3 days and measured after 11 days post compound removal by flow cytometry
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Butyrophilin subfamily 3 member A1 (CHEMBL4105758) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphonamidate Prodrugs of a Butyrophilin Ligand Display Plasma Stability and Potent Vγ9 Vδ2 T Cell Stimulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.84 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4203452 | — | — | 1 | 9.47 |
| CHEMBL4204044 | — | — | 1 | 9.44 |
| CHEMBL4215122 | — | — | 1 | 9.44 |
| CHEMBL4216254 | — | — | 1 | 9.36 |
| CHEMBL145233 | — | — | 1 | 9.29 |
| CHEMBL4215653 | — | — | 1 | 9.28 |
| CHEMBL4210700 | — | — | 1 | 9.24 |
| CHEMBL4207267 | — | — | 1 | 9.09 |
| CHEMBL4204584 | — | — | 1 | 8.96 |
| CHEMBL4208921 | — | — | 1 | 8.82 |
| CHEMBL4088948 | — | — | 1 | 8.27 |
| CHEMBL4172453 | — | — | 1 | 5.40 |
| CHEMBL4202914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4203452 | — | EC50 | = | 0.34 | nM | 9.47 |
| CHEMBL4204044 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL4215122 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL4216254 | — | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL145233 | — | EC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4215653 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL4210700 | — | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL4207267 | — | EC50 | = | 0.82 | nM | 9.09 |
| CHEMBL4204584 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4208921 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4088948 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4172453 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4202914 | — | EC50 | > | 10000.0 | nM | - |