Assay Detail
Binding
CHEMBL4201520
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BTN3A1 in human Vgamma9 Vdelta2 T cells mixed with human K562 cells pretreated with compound for 4 hrs assessed as INF-gamma production measured after 20 hrs by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Butyrophilin subfamily 3 member A1 (CHEMBL4105758) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphonamidate Prodrugs of a Butyrophilin Ligand Display Plasma Stability and Potent Vγ9 Vδ2 T Cell Stimulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.72 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215122 | — | — | 1 | 7.21 |
| CHEMBL4215653 | — | — | 1 | 7.03 |
| CHEMBL4210700 | — | — | 1 | 6.92 |
| CHEMBL4216254 | — | — | 1 | 6.89 |
| CHEMBL4204044 | — | — | 1 | 6.77 |
| CHEMBL4207267 | — | — | 1 | 6.68 |
| CHEMBL4203452 | — | — | 1 | 6.54 |
| CHEMBL4208921 | — | — | 1 | 6.34 |
| CHEMBL4204584 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215122 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4215653 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4210700 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4216254 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4204044 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4207267 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4203452 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4208921 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4204584 | — | EC50 | = | 740.0 | nM | 6.13 |