Assay Detail
Functional
CHEMBL4201615
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Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.51 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763342 | — | — | 1 | 8.15 |
| CHEMBL360648 | — | — | 1 | 8.10 |
| CHEMBL4217872 | — | — | 1 | 8.05 |
| CHEMBL4203314 | — | — | 1 | 7.30 |
| CHEMBL4216174 | — | — | 1 | 7.02 |
| CHEMBL4204210 | — | — | 1 | 7.00 |
| CHEMBL4212928 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763342 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL360648 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4217872 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4203314 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4216174 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4204210 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4212928 | — | IC50 | = | 110.0 | nM | 6.96 |