Assay Detail
Functional
CHEMBL4201652
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Agonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.69 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 8.70 |
| CHEMBL4204210 | — | — | 1 | 7.75 |
| CHEMBL3301668 | CARBETOCIN | 3.0 | 1 | 7.21 |
| CHEMBL3763342 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4204210 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3301668 | CARBETOCIN | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3763342 | — | EC50 | = | 78.0 | nM | 7.11 |