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Assay Detail

CHEMBL4201766

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human BACE1 using MOCA-SEV-NL-DAEFR-DNP-RR as substrate measured after 2 hrs by FRET assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-secretase 1 (CHEMBL4822)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

BACE1 Inhibitory Meroterpenoids from Aspergillus terreus.
Qi C, Liu M, Zhou Q, Gao W, Chen C, Lai Y, Hu Z, Xue Y, Zhang J, Li D, Li XN, Zhang Q, Wang J, Zhu H, Zhang Y.
J Nat Prod (2018) 81 : 1937 -1945
PubMed 30207465 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.36 6.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2333941 LY-2811376 1.0 1 6.21
CHEMBL4211219 1 5.48
CHEMBL4216181 1 5.23
CHEMBL4206426 1 4.50
CHEMBL4211731 1 -
CHEMBL4205875 1 -
CHEMBL4213164 1 -
CHEMBL4218091 1 -
CHEMBL4208768 1 -
CHEMBL4213706 1 -
CHEMBL4204435 1 -
CHEMBL4209304 1 -
CHEMBL4216625 1 -
CHEMBL4204943 1 -
CHEMBL4218151 1 -
CHEMBL4203972 1 -
CHEMBL4215650 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2333941 LY-2811376 IC50 = 620.0 nM 6.21
CHEMBL4211219 IC50 = 3320.0 nM 5.48
CHEMBL4216181 IC50 = 5850.0 nM 5.23
CHEMBL4206426 IC50 = 31680.0 nM 4.50
CHEMBL4211731 IC50 > 50000.0 nM -
CHEMBL4205875 IC50 > 50000.0 nM -
CHEMBL4213164 IC50 > 50000.0 nM -
CHEMBL4218091 IC50 > 50000.0 nM -
CHEMBL4208768 IC50 > 50000.0 nM -
CHEMBL4213706 IC50 > 50000.0 nM -
CHEMBL4204435 IC50 > 50000.0 nM -
CHEMBL4209304 IC50 > 50000.0 nM -
CHEMBL4216625 IC50 > 50000.0 nM -
CHEMBL4204943 IC50 > 50000.0 nM -
CHEMBL4218151 IC50 > 50000.0 nM -
CHEMBL4203972 IC50 > 50000.0 nM -
CHEMBL4215650 IC50 > 50000.0 nM -