Assay Detail
Binding
CHEMBL4201991
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Inhibition of human ALDH1A1
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.65 | 7.24 |
| Ki | 1 | 6.54 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3416563 | — | — | 1 | 7.24 |
| CHEMBL3276621 | — | — | 1 | 6.54 |
| CHEMBL4217738 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3416563 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3276621 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL4217738 | — | IC50 | = | 900.0 | nM | 6.05 |