Assay Detail
Binding
CHEMBL4202148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cell membranes
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.38 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207658 | — | — | 1 | 5.79 |
| CHEMBL4205254 | — | — | 2 | 5.61 |
| CHEMBL4202787 | — | — | 1 | 5.38 |
| CHEMBL4216117 | — | — | 1 | 5.14 |
| CHEMBL4214975 | — | — | 1 | - |
| CHEMBL4203894 | — | — | 1 | - |
| CHEMBL4208779 | — | — | 1 | - |
| CHEMBL4204449 | — | — | 1 | - |
| CHEMBL4212633 | — | — | 1 | - |
| CHEMBL4217581 | — | — | 1 | - |
| CHEMBL4208250 | — | — | 1 | - |
| CHEMBL4213176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207658 | — | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL4205254 | — | Ki | = | 2440.0 | nM | 5.61 |
| CHEMBL4202787 | — | Ki | = | 4170.0 | nM | 5.38 |
| CHEMBL4216117 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL4205254 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL4214975 | — | Ki | > | 9300.0 | nM | - |
| CHEMBL4203894 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4208779 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4204449 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4212633 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4217581 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4208250 | — | Ki | > | 7100.0 | nM | - |
| CHEMBL4213176 | — | Ki | > | 10000.0 | nM | - |