Assay Detail
Binding
CHEMBL4219684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human DAT
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.74 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228464 | — | — | 1 | 8.82 |
| CHEMBL4227100 | — | — | 1 | 8.30 |
| CHEMBL4227688 | — | — | 1 | 8.24 |
| CHEMBL1173532 | GSK1360707 | 1.0 | 1 | 8.00 |
| CHEMBL4224830 | — | — | 3 | 7.90 |
| CHEMBL4227955 | — | — | 1 | 7.40 |
| CHEMBL4227027 | — | — | 1 | 7.40 |
| CHEMBL4226867 | — | — | 1 | 7.10 |
| CHEMBL4225921 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228464 | — | Ki | = | 1.514 | nM | 8.82 |
| CHEMBL4227100 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL4227688 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL1173532 | GSK1360707 | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4224830 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL4224830 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL4224830 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL4227955 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL4227027 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL4226867 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL4225921 | — | Ki | = | 158.49 | nM | 6.80 |