Assay Detail
Binding
CHEMBL4219686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human NET
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.05 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228464 | — | — | 1 | 10.10 |
| CHEMBL4227688 | — | — | 1 | 8.85 |
| CHEMBL4227100 | — | — | 1 | 8.50 |
| CHEMBL4224830 | — | — | 3 | 8.40 |
| CHEMBL4226867 | — | — | 1 | 8.20 |
| CHEMBL1173532 | GSK1360707 | 1.0 | 1 | 8.10 |
| CHEMBL4227027 | — | — | 1 | 7.30 |
| CHEMBL4227955 | — | — | 1 | 7.10 |
| CHEMBL4225921 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228464 | — | Ki | = | 0.07943 | nM | 10.10 |
| CHEMBL4227688 | — | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL4227100 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL4224830 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL4226867 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1173532 | GSK1360707 | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL4224830 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4227027 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL4224830 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL4227955 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL4225921 | — | Ki | = | 158.49 | nM | 6.80 |