Assay Detail
Binding
CHEMBL4219712
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NET (unknown origin) assessed as reduction of [3H]-NE re-uptake
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.50 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326466 | — | — | 1 | 7.60 |
| CHEMBL111128 | — | — | 1 | 7.55 |
| CHEMBL109517 | — | — | 1 | 7.47 |
| CHEMBL113136 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326466 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL111128 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL109517 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL113136 | — | IC50 | = | 44.0 | nM | 7.36 |