Assay Detail
Binding
CHEMBL4219942
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assay
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pEC50 | 5 | - | - |
| EC50 | 4 | 6.11 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4227298 | — | — | 1 | 7.87 |
| CHEMBL4227048 | — | — | 1 | 6.18 |
| CHEMBL4228024 | — | — | 1 | 5.40 |
| CHEMBL4225948 | — | — | 1 | 4.99 |
| CHEMBL4226202 | — | — | 1 | - |
| CHEMBL4226258 | — | — | 1 | - |
| CHEMBL1331986 | — | — | 1 | - |
| CHEMBL4066349 | — | — | 1 | - |
| CHEMBL281071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4227298 | — | EC50 | = | 13.49 | nM | 7.87 |
| CHEMBL4227048 | — | EC50 | = | 660.69 | nM | 6.18 |
| CHEMBL4228024 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4225948 | — | EC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL4226202 | — | pEC50 | - | — | - | |
| CHEMBL4226258 | — | pEC50 | - | — | - | |
| CHEMBL1331986 | — | pEC50 | - | — | - | |
| CHEMBL4066349 | — | pEC50 | - | — | - | |
| CHEMBL281071 | — | pEC50 | - | — | - |