Assay Detail
Binding
CHEMBL4219947
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Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced response
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.80 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228372 | — | — | 1 | 10.22 |
| CHEMBL4227297 | — | — | 1 | 9.37 |
| CHEMBL4227144 | — | — | 1 | - |
| CHEMBL4226150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228372 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4227297 | — | EC50 | = | 0.43 | nM | 9.37 |
| CHEMBL4227144 | — | EC50 | = | 0.00016 | nM | - |
| CHEMBL4226150 | — | EC50 | = | 0.0012 | nM | - |