Assay Detail
Functional
CHEMBL4220181
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Agonist activity at human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gene assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of peptide-based polyagonists for treatment of diabetes and obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 10.35 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4226514 | — | — | 1 | 10.82 |
| CHEMBL4227045 | — | — | 1 | 10.70 |
| CHEMBL4226613 | — | — | 1 | 10.66 |
| CHEMBL4225594 | — | — | 1 | 10.52 |
| CHEMBL4225340 | — | — | 1 | 10.41 |
| CHEMBL4226185 | — | — | 1 | 10.40 |
| CHEMBL4224701 | — | — | 1 | 10.17 |
| CHEMBL4224968 | — | — | 1 | 10.03 |
| CHEMBL4226451 | — | — | 1 | 9.94 |
| CHEMBL4227861 | — | — | 1 | 9.85 |
| CHEMBL4229251 | — | — | 1 | - |
| CHEMBL4225795 | — | — | 1 | - |
| CHEMBL4227180 | — | — | 1 | - |
| CHEMBL4226634 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4226514 | — | EC50 | = | 0.015 | nM | 10.82 |
| CHEMBL4227045 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4226613 | — | EC50 | = | 0.022 | nM | 10.66 |
| CHEMBL4225594 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4225340 | — | EC50 | = | 0.039 | nM | 10.41 |
| CHEMBL4226185 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4224701 | — | EC50 | = | 0.068 | nM | 10.17 |
| CHEMBL4224968 | — | EC50 | = | 0.093 | nM | 10.03 |
| CHEMBL4226451 | — | EC50 | = | 0.115 | nM | 9.94 |
| CHEMBL4227861 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL4229251 | — | EC50 | = | 0.003 | nM | - |
| CHEMBL4225795 | — | EC50 | = | 0.003 | nM | - |
| CHEMBL4227180 | — | EC50 | = | 0.002 | nM | - |
| CHEMBL4226634 | — | EC50 | = | 0.004 | nM | - |