Assay Detail
Functional
CHEMBL4220182
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Agonist activity at human GCG receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gene assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of peptide-based polyagonists for treatment of diabetes and obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 10.12 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4226451 | — | — | 1 | 10.80 |
| CHEMBL4226514 | — | — | 1 | 10.55 |
| CHEMBL4227045 | — | — | 1 | 10.52 |
| CHEMBL4226613 | — | — | 1 | 10.51 |
| CHEMBL4225340 | — | — | 1 | 10.39 |
| CHEMBL4227861 | — | — | 1 | 9.82 |
| CHEMBL4225594 | — | — | 1 | 8.28 |
| CHEMBL4229251 | — | — | 1 | - |
| CHEMBL4224701 | — | — | 1 | - |
| CHEMBL4225795 | — | — | 1 | - |
| CHEMBL4224968 | — | — | 1 | - |
| CHEMBL4226185 | — | — | 1 | - |
| CHEMBL4227180 | — | — | 1 | - |
| CHEMBL4226634 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4226451 | — | EC50 | = | 0.016 | nM | 10.80 |
| CHEMBL4226514 | — | EC50 | = | 0.028 | nM | 10.55 |
| CHEMBL4227045 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4226613 | — | EC50 | = | 0.031 | nM | 10.51 |
| CHEMBL4225340 | — | EC50 | = | 0.041 | nM | 10.39 |
| CHEMBL4227861 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4225594 | — | EC50 | = | 5.225 | nM | 8.28 |
| CHEMBL4229251 | — | EC50 | = | 0.003 | nM | - |
| CHEMBL4224701 | — | EC50 | = | 0.005 | nM | - |
| CHEMBL4225795 | — | EC50 | = | 0.006 | nM | - |
| CHEMBL4224968 | — | EC50 | = | 0.005 | nM | - |
| CHEMBL4226185 | — | EC50 | = | 0.009 | nM | - |
| CHEMBL4227180 | — | EC50 | = | 0.004 | nM | - |
| CHEMBL4226634 | — | EC50 | = | 0.007 | nM | - |