Assay Detail
Functional
CHEMBL4220263
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Cytotoxicity against human SW620 cells after 72 hrs by MTS assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.23 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464221 | — | — | 1 | 6.30 |
| CHEMBL4228652 | — | — | 1 | 6.28 |
| CHEMBL4226832 | — | — | 1 | 5.95 |
| CHEMBL4227814 | — | — | 1 | 5.32 |
| CHEMBL512582 | — | — | 1 | 5.10 |
| CHEMBL4228850 | — | — | 1 | 5.07 |
| CHEMBL4227884 | — | — | 1 | 4.92 |
| CHEMBL4228134 | — | — | 1 | 4.89 |
| CHEMBL4227025 | — | — | 1 | 4.68 |
| CHEMBL4227885 | — | — | 1 | 4.55 |
| CHEMBL4227280 | — | — | 1 | 4.42 |
| CHEMBL4225092 | — | — | 1 | - |
| CHEMBL4228393 | — | — | 1 | - |
| CHEMBL4227346 | — | — | 1 | - |
| CHEMBL4226492 | — | — | 1 | - |
| CHEMBL4227767 | — | — | 1 | - |
| CHEMBL464223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464221 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4228652 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4226832 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4227814 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL512582 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4228850 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4227884 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4228134 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4227025 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4227885 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4227280 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4225092 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4228393 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4227346 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4226492 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4227767 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL464223 | — | IC50 | > | 50000.0 | nM | - |