Assay Detail
Binding
CHEMBL4221124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-mediated SEAP production preincubated for 2 hrs followed by LPS stimulation for 20 hrs by colorimetric assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.23 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228510 | — | — | 1 | 6.27 |
| CHEMBL225157 | RESATORVID | 3.0 | 1 | 6.17 |
| CHEMBL4228911 | — | — | 1 | 5.27 |
| CHEMBL4227459 | — | — | 1 | 4.72 |
| CHEMBL4229108 | — | — | 1 | 4.59 |
| CHEMBL4225876 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228510 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL225157 | RESATORVID | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4228911 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL4227459 | — | IC50 | = | 19250.0 | nM | 4.72 |
| CHEMBL4229108 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL4225876 | — | IC50 | = | 45650.0 | nM | 4.34 |