Assay Detail
Binding
CHEMBL4221599
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Inhibition of recombinant human MAO-B using kynuramine as substrate after 30 mins by fluorescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.06 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.08 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.71 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.38 |
| CHEMBL4228361 | — | — | 1 | 4.91 |
| CHEMBL4228401 | — | — | 1 | 4.88 |
| CHEMBL4228676 | — | — | 1 | 4.86 |
| CHEMBL4227568 | — | — | 1 | 4.73 |
| CHEMBL4226833 | — | — | 1 | 4.72 |
| CHEMBL4227620 | — | — | 1 | 4.71 |
| CHEMBL4226245 | — | — | 1 | 4.71 |
| CHEMBL4228589 | — | — | 1 | 4.71 |
| CHEMBL4225991 | — | — | 1 | 4.70 |
| CHEMBL4224820 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL4228361 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4228401 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4228676 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL4227568 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL4226833 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4227620 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL4226245 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL4228589 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL4225991 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL4224820 | — | IC50 | = | 20100.0 | nM | 4.70 |