Assay Detail
Functional
CHEMBL4221741
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.62 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228029 | — | — | 1 | 7.70 |
| CHEMBL4228933 | — | — | 1 | 7.10 |
| CHEMBL4224838 | — | — | 1 | 6.44 |
| CHEMBL4225687 | — | — | 1 | 6.16 |
| CHEMBL4225107 | — | — | 1 | 6.03 |
| CHEMBL4226651 | — | — | 1 | 5.83 |
| CHEMBL4229138 | — | — | 1 | 5.54 |
| CHEMBL4228803 | — | — | 1 | 5.30 |
| CHEMBL4227352 | — | — | 1 | 5.13 |
| CHEMBL4228358 | — | — | 1 | 5.00 |
| CHEMBL4226191 | — | — | 1 | 4.63 |
| CHEMBL4225631 | — | — | 1 | 4.18 |
| CHEMBL4225375 | — | — | 1 | 4.04 |
| CHEMBL4225162 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228029 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4228933 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4224838 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4225687 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4225107 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4226651 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4229138 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4228803 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL4227352 | — | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL4228358 | — | IC50 | = | 9930.0 | nM | 5.00 |
| CHEMBL4226191 | — | IC50 | = | 23350.0 | nM | 4.63 |
| CHEMBL4225631 | — | IC50 | = | 66140.0 | nM | 4.18 |
| CHEMBL4225375 | — | IC50 | = | 90090.0 | nM | 4.04 |
| CHEMBL4225162 | — | IC50 | > | 100000.0 | nM | - |