Assay Detail
Functional
CHEMBL4222055
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Antiinflammatory activity in human HMC1 cells assessed as reduction in PMA/ionophore A23187-induced IL-6 production
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMC1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.62 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228035 | — | — | 1 | 5.71 |
| CHEMBL4228873 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228035 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4228873 | — | IC50 | = | 2960.0 | nM | 5.53 |