Assay Detail
Binding
CHEMBL4222299
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Inverse agonist activity at GAL4-DNA binding domain-fused human RORbeta ligand binding domain expressed in HEK293T cells incubated for 20 hrs by luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an aminothiazole series of RORβ modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 4 | - | - |
| IC50 | 1 | 6.07 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4225808 | — | — | 1 | 6.07 |
| CHEMBL4226071 | — | — | 1 | - |
| CHEMBL4226645 | — | — | 1 | - |
| CHEMBL4225264 | — | — | 1 | - |
| CHEMBL4227867 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4225808 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4226071 | — | Activity | - | — | - | |
| CHEMBL4226645 | — | Activity | - | — | - | |
| CHEMBL4225264 | — | Activity | - | — | - | |
| CHEMBL4227867 | — | Activity | - | — | - |