Assay Detail
Binding
CHEMBL4222448
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Inhibition of FLT3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.15 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4228240 | — | — | 1 | 8.30 |
| CHEMBL4225923 | — | — | 1 | 8.30 |
| CHEMBL4227082 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4228240 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4225923 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4227082 | — | IC50 | = | 14.0 | nM | 7.85 |