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Assay Detail

CHEMBL4222567

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to N-terminally acetylated human UBE2M
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

NEDD8-conjugating enzyme Ubc12 (CHEMBL4295787)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
Hammill JT, Scott DC, Min J, Connelly MC, Holbrook G, Zhu F, Matheny A, Yang L, Singh B, Schulman BA, Guy RK.
J Med Chem (2018) 61 : 2680 -2693
PubMed 29547696 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.00 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4099097 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4099097 Kd = 1000.0 nM 6.00