Assay Detail
Functional
CHEMBL4222806
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human BxPC3 cells after 72 hrs by sulforhodamine B assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and biological evaluation of anti-pancreatic cancer activity of plinabulin derivatives based on the co-crystal structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.96 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2024561 | — | — | 1 | 9.20 |
| CHEMBL4225376 | — | — | 1 | 8.81 |
| CHEMBL4227940 | — | — | 1 | 8.76 |
| CHEMBL4226762 | — | — | 1 | 8.39 |
| CHEMBL1096380 | PLINABULIN | 3.0 | 1 | 8.37 |
| CHEMBL3342339 | — | — | 1 | 8.20 |
| CHEMBL4226910 | — | — | 1 | 8.12 |
| CHEMBL4225738 | — | — | 1 | 8.04 |
| CHEMBL4226579 | — | — | 1 | 8.03 |
| CHEMBL4227131 | — | — | 1 | 7.77 |
| CHEMBL4225066 | — | — | 1 | 7.62 |
| CHEMBL4228619 | — | — | 1 | 7.00 |
| CHEMBL4226315 | — | — | 1 | 6.59 |
| CHEMBL4224871 | — | — | 1 | 6.49 |
| CHEMBL4226696 | — | — | 1 | - |
| CHEMBL4226643 | — | — | 1 | - |
| CHEMBL4225120 | — | — | 1 | - |
| CHEMBL4225272 | — | — | 1 | - |
| CHEMBL4226928 | — | — | 1 | - |
| CHEMBL4228688 | — | — | 1 | - |
| CHEMBL4226520 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2024561 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4225376 | — | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL4227940 | — | IC50 | = | 1.72 | nM | 8.76 |
| CHEMBL4226762 | — | IC50 | = | 4.05 | nM | 8.39 |
| CHEMBL1096380 | PLINABULIN | IC50 | = | 4.28 | nM | 8.37 |
| CHEMBL3342339 | — | IC50 | = | 6.27 | nM | 8.20 |
| CHEMBL4226910 | — | IC50 | = | 7.58 | nM | 8.12 |
| CHEMBL4225738 | — | IC50 | = | 9.23 | nM | 8.04 |
| CHEMBL4226579 | — | IC50 | = | 9.41 | nM | 8.03 |
| CHEMBL4227131 | — | IC50 | = | 17.11 | nM | 7.77 |
| CHEMBL4225066 | — | IC50 | = | 23.78 | nM | 7.62 |
| CHEMBL4228619 | — | IC50 | = | 100.4 | nM | 7.00 |
| CHEMBL4226315 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4224871 | — | IC50 | = | 324.9 | nM | 6.49 |
| CHEMBL4226696 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4226643 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4225120 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4225272 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4226928 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4228688 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4226520 | — | IC50 | > | 100.0 | nM | - |