Assay Detail
Functional
CHEMBL4222841
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Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.93 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4225306 | — | — | 1 | 6.62 |
| CHEMBL4225565 | — | — | 1 | 6.37 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 6.31 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.90 |
| CHEMBL4226151 | — | — | 1 | 5.53 |
| CHEMBL4226937 | — | — | 1 | 5.47 |
| CHEMBL4228518 | — | — | 1 | 5.31 |
| CHEMBL4227084 | — | — | 1 | - |
| CHEMBL4225951 | — | — | 1 | - |
| CHEMBL4226676 | — | — | 1 | - |
| CHEMBL4225777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4225306 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL4225565 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL4226151 | — | IC50 | = | 2945.0 | nM | 5.53 |
| CHEMBL4226937 | — | IC50 | = | 3362.0 | nM | 5.47 |
| CHEMBL4228518 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL4227084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4225951 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4226676 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4225777 | — | IC50 | > | 10000.0 | nM | - |