Assay Detail
Functional
CHEMBL4222857
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Antifungal activity against wild-type fluconazole-sensitive Cryptococcus neoformans serotype D B3501 measured over 4 days
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cryptococcus neoformans |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.62 | 6.89 |
| MIC=>90 | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106 | FLUCONAZOLE | 4.0 | 2 | 6.89 |
| CHEMBL4226423 | — | — | 2 | 6.80 |
| CHEMBL3394576 | — | — | 2 | 6.75 |
| CHEMBL4228173 | — | — | 2 | 6.57 |
| CHEMBL4226692 | — | — | 2 | 6.50 |
| CHEMBL4229022 | — | — | 2 | 6.42 |
| CHEMBL4229230 | — | — | 2 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4226423 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3394576 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4228173 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4226692 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4229022 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4229230 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3394576 | — | MIC=>90 | = | 0.63 | uM | - |
| CHEMBL4228173 | — | MIC=>90 | = | 0.63 | uM | - |
| CHEMBL4226692 | — | MIC=>90 | = | 0.63 | uM | - |
| CHEMBL4226423 | — | MIC=>90 | = | 0.63 | uM | - |
| CHEMBL4229230 | — | MIC=>90 | = | 1.25 | uM | - |
| CHEMBL4229022 | — | MIC=>90 | = | 1.25 | uM | - |
| CHEMBL106 | FLUCONAZOLE | MIC=>90 | = | 2.04 | uM | - |