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Assay Detail

CHEMBL4222864

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity against Histoplasma capsulatum G217B ATCC 26032 at pH 5 measured over 5 days
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Histoplasma capsulatum
Confidence 1 — Organism
Curated By Intermediate

Target

Histoplasma capsulatum (CHEMBL614625)
Type ORGANISM
Organism Histoplasma capsulatum

Publication

Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans.
Ishita K, Stefanopoulos S, Khalil A, Cheng X, Tjarks W, Rappleye CA.
Bioorg Med Chem (2018) 26 : 2251 -2261
PubMed 29580849 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.93 5.17
MIC=>90 9 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3394576 2 5.17
CHEMBL4228482 2 4.96
CHEMBL4228657 2 4.80
CHEMBL4227462 2 4.78
CHEMBL4227845 2 -
CHEMBL4227872 2 -
CHEMBL4224873 2 -
CHEMBL4228352 2 -
CHEMBL4225353 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3394576 IC50 = 6750.0 nM 5.17
CHEMBL4228482 IC50 = 11080.0 nM 4.96
CHEMBL4228657 IC50 = 15670.0 nM 4.80
CHEMBL4227462 IC50 = 16780.0 nM 4.78
CHEMBL4227845 IC50 > 20000.0 nM -
CHEMBL4227872 IC50 > 20000.0 nM -
CHEMBL4224873 IC50 > 20000.0 nM -
CHEMBL4228352 IC50 > 20000.0 nM -
CHEMBL4225353 IC50 > 20000.0 nM -
CHEMBL3394576 MIC=>90 = 10.0 uM -
CHEMBL4228657 MIC=>90 = 40.0 uM -
CHEMBL4227462 MIC=>90 = 40.0 uM -
CHEMBL4227845 MIC=>90 > 40.0 uM -
CHEMBL4227872 MIC=>90 > 40.0 uM -
CHEMBL4224873 MIC=>90 > 40.0 uM -
CHEMBL4228482 MIC=>90 = 40.0 uM -
CHEMBL4228352 MIC=>90 > 40.0 uM -
CHEMBL4225353 MIC=>90 > 40.0 uM -