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Assay Detail

CHEMBL4222865

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity against wild type fluconazole-sensitive Cryptococcus neoformans serotype A H99 at pH 5 measured over 4 days
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cryptococcus neoformans
Confidence 1 — Organism
Curated By Intermediate

Target

Cryptococcus neoformans (CHEMBL365)
Type ORGANISM
Organism Cryptococcus neoformans

Publication

Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans.
Ishita K, Stefanopoulos S, Khalil A, Cheng X, Tjarks W, Rappleye CA.
Bioorg Med Chem (2018) 26 : 2251 -2261
PubMed 29580849 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 5.23 5.52
MIC=>90 9 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3394576 2 5.52
CHEMBL4227462 2 5.37
CHEMBL4227872 2 4.81
CHEMBL4228657 2 -
CHEMBL4227845 2 -
CHEMBL4224873 2 -
CHEMBL4228482 2 -
CHEMBL4228352 2 -
CHEMBL4225353 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3394576 IC50 = 3040.0 nM 5.52
CHEMBL4227462 IC50 = 4290.0 nM 5.37
CHEMBL4227872 IC50 = 15570.0 nM 4.81
CHEMBL4228657 IC50 > 20000.0 nM -
CHEMBL4227845 IC50 > 20000.0 nM -
CHEMBL4224873 IC50 > 20000.0 nM -
CHEMBL4228482 IC50 > 20000.0 nM -
CHEMBL4228352 IC50 > 20000.0 nM -
CHEMBL4225353 IC50 > 20000.0 nM -
CHEMBL4228657 MIC=>90 > 40.0 uM -
CHEMBL4227462 MIC=>90 = 10.0 uM -
CHEMBL4227845 MIC=>90 > 40.0 uM -
CHEMBL4227872 MIC=>90 > 40.0 uM -
CHEMBL4224873 MIC=>90 > 40.0 uM -
CHEMBL4228482 MIC=>90 > 40.0 uM -
CHEMBL4228352 MIC=>90 > 40.0 uM -
CHEMBL4225353 MIC=>90 > 40.0 uM -
CHEMBL3394576 MIC=>90 = 5.0 uM -