Assay Detail
Binding
CHEMBL4222925
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Inhibition of biotin labelled Pam2CSK4 binding to mouse TLR2 Fc chimera protein after 45 mins by AlphaScreen assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Site-specific effect of polar functional group-modification in lipids of TLR2 ligands for modulating the ligand immunostimulatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.69 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179400 | — | — | 1 | 6.46 |
| CHEMBL4225423 | — | — | 1 | 5.98 |
| CHEMBL4226256 | — | — | 1 | 5.86 |
| CHEMBL4227905 | — | — | 1 | 5.32 |
| CHEMBL4225148 | — | — | 1 | 5.25 |
| CHEMBL4224884 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179400 | — | IC50 | = | 349.2 | nM | 6.46 |
| CHEMBL4225423 | — | IC50 | = | 1039.0 | nM | 5.98 |
| CHEMBL4226256 | — | IC50 | = | 1382.0 | nM | 5.86 |
| CHEMBL4227905 | — | IC50 | = | 4748.0 | nM | 5.32 |
| CHEMBL4225148 | — | IC50 | = | 5612.0 | nM | 5.25 |
| CHEMBL4224884 | — | IC50 | = | 5694.0 | nM | 5.25 |