Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4222934

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasitic activity against tachyzoite stage of Toxoplasma gondii expressing beta-gal infected in HFF after 4 days by chlorophenol red-beta-D-galactosidase based assay
ChEMBL ↗
66
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Toxoplasma gondii
Cell Type HFF
Confidence 1 — Organism
Curated By Intermediate

Target

Toxoplasma gondii (CHEMBL612888) ↗
Type ORGANISM
Organism Toxoplasma gondii

Publication

One-pot, multicomponent synthesis of 2,3-disubstituted quinazolin-ones with potent and selective activity against Toxoplasma gondii.
Brown CE, Kong T, Bordón C, Yolken R, Jones-Brando L, McNulty J.
Bioorg Med Chem Lett (2018) 28 : 1642 -1646
PubMed 29598911 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 4.78 6.70
IC90 33 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1450 ATOVAQUONE 4.0 2 6.70
CHEMBL269671 ARTEMISININ 3.0 2 5.70
CHEMBL4087426 — — 2 5.52
CHEMBL4105280 — — 2 5.40
CHEMBL4224737 — — 2 5.22
CHEMBL4225675 — — 2 5.16
CHEMBL4095115 — — 2 5.00
CHEMBL4227501 — — 2 5.00
CHEMBL153452 — — 2 4.92
CHEMBL4228884 — — 2 4.92
CHEMBL4228765 — — 2 4.89
CHEMBL1333995 — — 2 4.85
CHEMBL4228248 — — 2 4.82
CHEMBL4228507 — — 2 4.77
CHEMBL152046 — — 2 4.75
CHEMBL336718 — — 2 4.70
CHEMBL4225119 — — 2 4.60
CHEMBL4225548 — — 2 4.57
CHEMBL18688 — — 2 4.54
CHEMBL4078597 — — 2 4.51
CHEMBL4226131 — — 2 4.50
CHEMBL4229196 — — 2 4.46
CHEMBL4227231 — — 2 4.40
CHEMBL4102877 — — 2 4.36
CHEMBL4228626 — — 2 4.31
CHEMBL4077094 — — 2 4.30
CHEMBL342675 — — 2 4.25
CHEMBL4226656 — — 2 4.22
CHEMBL2058057 — — 2 4.04
CHEMBL1429848 — — 2 4.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1450 ATOVAQUONE IC50 = 200.0 nM 6.70
CHEMBL269671 ARTEMISININ IC50 = 2000.0 nM 5.70
CHEMBL4087426 — IC50 = 3000.0 nM 5.52
CHEMBL4105280 — IC50 = 4000.0 nM 5.40
CHEMBL4224737 — IC50 = 6000.0 nM 5.22
CHEMBL4225675 — IC50 = 7000.0 nM 5.16
CHEMBL4095115 — IC50 = 10000.0 nM 5.00
CHEMBL4227501 — IC50 = 10000.0 nM 5.00
CHEMBL153452 — IC50 = 12000.0 nM 4.92
CHEMBL4228884 — IC50 = 12000.0 nM 4.92
CHEMBL4228765 — IC50 = 13000.0 nM 4.89
CHEMBL1333995 — IC50 = 14000.0 nM 4.85
CHEMBL4228248 — IC50 = 15000.0 nM 4.82
CHEMBL4228507 — IC50 = 17000.0 nM 4.77
CHEMBL152046 — IC50 = 18000.0 nM 4.75
CHEMBL336718 — IC50 = 20000.0 nM 4.70
CHEMBL4225119 — IC50 = 25000.0 nM 4.60
CHEMBL4225548 — IC50 = 27000.0 nM 4.57
CHEMBL18688 — IC50 = 29000.0 nM 4.54
CHEMBL4078597 — IC50 = 31000.0 nM 4.51
CHEMBL4226131 — IC50 = 32000.0 nM 4.50
CHEMBL4229196 — IC50 = 35000.0 nM 4.46
CHEMBL4227231 — IC50 = 40000.0 nM 4.40
CHEMBL4102877 — IC50 = 44000.0 nM 4.36
CHEMBL4228626 — IC50 = 49000.0 nM 4.31
CHEMBL4077094 — IC50 = 50000.0 nM 4.30
CHEMBL342675 — IC50 = 56000.0 nM 4.25
CHEMBL4226656 — IC50 = 60000.0 nM 4.22
CHEMBL2058057 — IC50 = 92000.0 nM 4.04
CHEMBL1429848 — IC50 = 94000.0 nM 4.03
CHEMBL4228822 — IC50 = 112000.0 nM -
CHEMBL342675 — IC90 = 266000.0 nM -
CHEMBL4228364 — IC90 = 724000.0 nM -
CHEMBL4229196 — IC90 = 116000.0 nM -
CHEMBL269671 ARTEMISININ IC90 = 19000.0 nM -
CHEMBL4228626 — IC90 = 170000.0 nM -
CHEMBL4225675 — IC90 = 58000.0 nM -
CHEMBL4228884 — IC90 = 55000.0 nM -
CHEMBL4225119 — IC90 = 119000.0 nM -
CHEMBL152046 — IC90 = 52000.0 nM -
CHEMBL4228765 — IC90 = 71000.0 nM -
CHEMBL4224737 — IC90 = 46000.0 nM -
CHEMBL4228507 — IC90 = 52000.0 nM -
CHEMBL153452 — IC90 = 60000.0 nM -
CHEMBL4228248 — IC90 = 67000.0 nM -
CHEMBL4228822 — IC90 = 353000.0 nM -
CHEMBL1450 ATOVAQUONE IC90 = 600.0 nM -
CHEMBL4087426 — IC90 = 12000.0 nM -
CHEMBL4102877 — IC90 = 126000.0 nM -
CHEMBL4078597 — IC90 = 83000.0 nM -