Assay Detail
Binding
CHEMBL4223235
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human Cav3.2-alpha1 expressed in HEK293T cells assessed as decrease in KCl-induced calcium mobilization measured after 600 secs post compound addition and 300 secs post KCl addition by calcium 4 dye-based FLIPR assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent T-type calcium channel subunit alpha-1H (CHEMBL1859) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.49 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4227475 | — | — | 1 | 5.70 |
| CHEMBL4226823 | — | — | 1 | 4.39 |
| CHEMBL604710 | Z160 | 2.0 | 1 | 4.35 |
| CHEMBL4226674 | — | — | 1 | 4.27 |
| CHEMBL4227450 | — | — | 1 | 4.19 |
| CHEMBL4225603 | — | — | 1 | 4.02 |
| CHEMBL4226597 | — | — | 1 | - |
| CHEMBL4229218 | — | — | 1 | - |
| CHEMBL4227740 | — | — | 1 | - |
| CHEMBL4226078 | — | — | 1 | - |
| CHEMBL4226924 | — | — | 1 | - |
| CHEMBL4224756 | — | — | 1 | - |
| CHEMBL4229102 | — | — | 1 | - |
| CHEMBL4225354 | — | — | 1 | - |
| CHEMBL4225288 | — | — | 1 | - |
| CHEMBL4226136 | — | — | 1 | - |
| CHEMBL4225014 | — | — | 1 | - |
| CHEMBL4225787 | — | — | 1 | - |
| CHEMBL4225492 | — | — | 1 | - |
| CHEMBL4226327 | — | — | 1 | - |
| CHEMBL4225227 | — | — | 1 | - |
| CHEMBL4226080 | — | — | 1 | - |
| CHEMBL4224963 | — | — | 1 | - |
| CHEMBL4225815 | — | — | 1 | - |
| CHEMBL4226804 | — | — | 1 | - |
| CHEMBL4227653 | — | — | 1 | - |
| CHEMBL4228579 | — | — | 1 | - |
| CHEMBL4224809 | — | — | 1 | - |
| CHEMBL4228834 | — | — | 1 | - |
| CHEMBL4225757 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4227475 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4226823 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL604710 | Z160 | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4226674 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4227450 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL4225603 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL4227740 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL4224750 | — | IC50 | = | 171000.0 | nM | - |
| CHEMBL4226078 | — | IC50 | = | 248000.0 | nM | - |
| CHEMBL4226924 | — | IC50 | = | 492000.0 | nM | - |
| CHEMBL4224756 | — | IC50 | = | 165000.0 | nM | - |
| CHEMBL4229102 | — | IC50 | = | 326000.0 | nM | - |
| CHEMBL4225354 | — | IC50 | = | 270000.0 | nM | - |
| CHEMBL4225288 | — | IC50 | = | 195000.0 | nM | - |
| CHEMBL4226136 | — | IC50 | = | 288000.0 | nM | - |
| CHEMBL4225014 | — | IC50 | = | 319000.0 | nM | - |
| CHEMBL4225787 | — | IC50 | = | 166000.0 | nM | - |
| CHEMBL4229218 | — | IC50 | = | 109000.0 | nM | - |
| CHEMBL4226597 | — | IC50 | = | 328000.0 | nM | - |
| CHEMBL4225492 | — | IC50 | = | 498000.0 | nM | - |
| CHEMBL4226327 | — | IC50 | = | 332000.0 | nM | - |
| CHEMBL4225227 | — | IC50 | = | 521000.0 | nM | - |
| CHEMBL4226080 | — | IC50 | = | 212000.0 | nM | - |
| CHEMBL4224963 | — | IC50 | = | 771000.0 | nM | - |
| CHEMBL4225815 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL4226804 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4227653 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4228579 | — | IC50 | = | 688000.0 | nM | - |
| CHEMBL4224809 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL4228834 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4225757 | — | IC50 | = | 239000.0 | nM | - |