Assay Detail
Binding
CHEMBL4223410
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Binding affinity to human dopamine D3 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D3 receptor ligands with extended functionality for probing the secondary binding pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.82 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201343 | — | — | 1 | 9.30 |
| CHEMBL81675 | — | — | 1 | 7.28 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201343 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL81675 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL7549 | PRECLAMOL | Ki | = | 132.0 | nM | 6.88 |