Assay Detail
Binding
CHEMBL4223422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to CA-SP1 P373S mutant in HIV-1 subtype B NL4-3 infected in human MT2 cells assessed as inhibition of viral maturation by measuring virus yields after 4 to 5 days in presence of 10% FBS by luciferase reporter gene assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Gag-Pol polyprotein (CHEMBL3638360) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) |
Publication
The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 8.51 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4226862 | — | — | 1 | 9.47 |
| CHEMBL3828596 | — | — | 1 | 9.17 |
| CHEMBL4225363 | — | — | 1 | 9.15 |
| CHEMBL4225028 | — | — | 1 | 9.15 |
| CHEMBL4226018 | — | — | 1 | 9.11 |
| CHEMBL3827026 | — | — | 1 | 9.00 |
| CHEMBL4228854 | — | — | 1 | 8.85 |
| CHEMBL4225004 | — | — | 1 | 8.85 |
| CHEMBL4224769 | — | — | 1 | 8.82 |
| CHEMBL4225279 | — | — | 1 | 8.77 |
| CHEMBL4224747 | — | — | 1 | 8.70 |
| CHEMBL4225441 | — | — | 1 | 8.70 |
| CHEMBL4228598 | — | — | 1 | 8.70 |
| CHEMBL3827839 | — | — | 1 | 8.66 |
| CHEMBL3787468 | — | — | 1 | 8.64 |
| CHEMBL4227119 | — | — | 1 | 8.60 |
| CHEMBL4226544 | — | — | 1 | 8.57 |
| CHEMBL4225753 | — | — | 1 | 8.57 |
| CHEMBL4225614 | — | — | 1 | 8.55 |
| CHEMBL4228517 | — | — | 1 | 8.48 |
| CHEMBL4226921 | — | — | 1 | 8.37 |
| CHEMBL4227382 | — | — | 1 | 8.33 |
| CHEMBL4225093 | — | — | 1 | 8.30 |
| CHEMBL4226272 | — | — | 1 | 8.22 |
| CHEMBL4226454 | — | — | 1 | 8.17 |
| CHEMBL4229111 | — | — | 1 | 8.11 |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | 8.00 |
| CHEMBL4225865 | — | — | 1 | 7.85 |
| CHEMBL4227326 | — | — | 1 | 7.80 |
| CHEMBL3775172 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4226862 | — | EC50 | = | 0.34 | nM | 9.47 |
| CHEMBL3828596 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL4225363 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4225028 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4226018 | — | EC50 | = | 0.78 | nM | 9.11 |
| CHEMBL3827026 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4228854 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4225004 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4224769 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4225279 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4224747 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4225441 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4228598 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3827839 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3787468 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4227119 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4226544 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4225753 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4225614 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4228517 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4226921 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4227382 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4225093 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4226272 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4226454 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4229111 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL404519 | BEVIRIMAT | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4225865 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4227326 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3775172 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4228038 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4224822 | — | EC50 | = | 51.0 | nM | 7.29 |