Assay Detail
Binding
CHEMBL4223479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of African green monkey SOAT1 expressed in CHO cells assessed as decrease in [14C]CE synthesis from [14C]oleic acid after 6 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Chlorocebus aethiops |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sterol O-acyltransferase 1 (CHEMBL3879850) ↗| Type | SINGLE PROTEIN |
| Organism | Chlorocebus aethiops |
Publication
Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.82 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4227742 | — | — | 1 | 6.11 |
| CHEMBL409855 | BEAUVERIOLIDE III | — | 1 | 5.96 |
| CHEMBL4228016 | — | — | 1 | 5.92 |
| CHEMBL4227559 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4227742 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL409855 | BEAUVERIOLIDE III | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4228016 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4227559 | — | IC50 | = | 5200.0 | nM | 5.28 |