Assay Detail
Binding
CHEMBL4223564
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET peptide substrate by FRET assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231) ↗| Type | PROTEIN COMPLEX |
| Organism | Hepatitis C virus |
Publication
P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.74 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4226033 | — | — | 1 | 10.30 |
| CHEMBL4226876 | — | — | 1 | 9.72 |
| CHEMBL4225009 | — | — | 1 | 9.68 |
| CHEMBL4228791 | — | — | 1 | 9.66 |
| CHEMBL4228440 | — | — | 1 | 9.62 |
| CHEMBL4225149 | — | — | 1 | 9.57 |
| CHEMBL4225051 | — | — | 1 | 9.52 |
| CHEMBL4225768 | — | — | 1 | 9.47 |
| CHEMBL4225514 | — | — | 1 | 9.40 |
| CHEMBL4229110 | — | — | 1 | 9.36 |
| CHEMBL4229052 | — | — | 1 | 9.34 |
| CHEMBL4224705 | — | — | 1 | 9.15 |
| CHEMBL4225301 | — | — | 1 | 9.09 |
| CHEMBL4228533 | — | — | 1 | 9.05 |
| CHEMBL2105735 | ASUNAPREVIR | 4.0 | 1 | 9.00 |
| CHEMBL4227396 | — | — | 1 | 8.92 |
| CHEMBL4228402 | — | — | 1 | 8.77 |
| CHEMBL4228282 | — | — | 1 | 8.70 |
| CHEMBL2403888 | — | — | 1 | 8.70 |
| CHEMBL4229158 | — | — | 1 | 8.64 |
| CHEMBL4227401 | — | — | 1 | 8.60 |
| CHEMBL4226548 | — | — | 1 | 8.59 |
| CHEMBL4225716 | — | — | 1 | 8.55 |
| CHEMBL4225561 | — | — | 1 | 8.46 |
| CHEMBL414993 | — | — | 1 | 8.35 |
| CHEMBL4224849 | — | — | 1 | 8.34 |
| CHEMBL4226979 | — | — | 1 | 8.33 |
| CHEMBL4227183 | — | — | 1 | 8.10 |
| CHEMBL4228080 | — | — | 1 | 8.00 |
| CHEMBL4225245 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4226033 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL4226876 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4225009 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL4228791 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL4228440 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL4225149 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL4225051 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4225768 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL4225514 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4229110 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL4229052 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL4224705 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4225301 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL4228533 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2105735 | ASUNAPREVIR | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4227396 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4228402 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4228282 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2403888 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4229158 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4227401 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4226548 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4225716 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4225561 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL414993 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4224849 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4226979 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4227183 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4228080 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4225245 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4228457 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4228717 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4225027 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4224783 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4227273 | — | IC50 | = | 945.0 | nM | 6.03 |