Assay Detail
Binding
CHEMBL4223567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal poly-His tagged recombinant HCV genotype 2b NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET peptide substrate by FRET assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2b |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231) ↗| Type | PROTEIN COMPLEX |
| Organism | Hepatitis C virus |
Publication
P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.39 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4227183 | — | — | 1 | 8.49 |
| CHEMBL4224849 | — | — | 1 | 8.15 |
| CHEMBL4229158 | — | — | 1 | 8.06 |
| CHEMBL4226033 | — | — | 1 | 8.05 |
| CHEMBL4228440 | — | — | 1 | 7.85 |
| CHEMBL4225051 | — | — | 1 | 7.85 |
| CHEMBL4225514 | — | — | 1 | 7.77 |
| CHEMBL414993 | — | — | 1 | 7.75 |
| CHEMBL4225768 | — | — | 1 | 7.72 |
| CHEMBL4225149 | — | — | 1 | 7.72 |
| CHEMBL4225009 | — | — | 1 | 7.64 |
| CHEMBL4229110 | — | — | 1 | 7.51 |
| CHEMBL4229052 | — | — | 1 | 7.48 |
| CHEMBL4228791 | — | — | 1 | 7.38 |
| CHEMBL4226876 | — | — | 1 | 7.23 |
| CHEMBL4224705 | — | — | 1 | 7.23 |
| CHEMBL4227396 | — | — | 1 | 7.18 |
| CHEMBL4225301 | — | — | 1 | 6.94 |
| CHEMBL4228282 | — | — | 1 | 6.92 |
| CHEMBL4227401 | — | — | 1 | 6.76 |
| CHEMBL4226548 | — | — | 1 | 6.74 |
| CHEMBL2403888 | — | — | 1 | 6.73 |
| CHEMBL4226979 | — | — | 1 | 6.65 |
| CHEMBL4225245 | — | — | 1 | 6.56 |
| CHEMBL4225561 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4227183 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4224849 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4229158 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4226033 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4228440 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4225051 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4225514 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL414993 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4225768 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4225149 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4225009 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4229110 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4229052 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4228791 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4226876 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4224705 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4227396 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4225301 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4228282 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL4227401 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL4226548 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL2403888 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4226979 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL4225245 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL4225561 | — | IC50 | = | 327.0 | nM | 6.49 |