Assay Detail
Binding
CHEMBL4223568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal poly-His tagged recombinant HCV genotype 3a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET peptide substrate by FRET assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 3a |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231) ↗| Type | PROTEIN COMPLEX |
| Organism | Hepatitis C virus |
Publication
P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.21 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4224849 | — | — | 1 | 8.13 |
| CHEMBL4226033 | — | — | 1 | 7.96 |
| CHEMBL4225009 | — | — | 1 | 7.82 |
| CHEMBL4227183 | — | — | 1 | 7.80 |
| CHEMBL4228440 | — | — | 1 | 7.80 |
| CHEMBL4229158 | — | — | 1 | 7.77 |
| CHEMBL414993 | — | — | 1 | 7.75 |
| CHEMBL4225149 | — | — | 1 | 7.75 |
| CHEMBL4225051 | — | — | 1 | 7.58 |
| CHEMBL4224705 | — | — | 1 | 7.47 |
| CHEMBL4225768 | — | — | 1 | 7.39 |
| CHEMBL4229110 | — | — | 1 | 7.22 |
| CHEMBL4229052 | — | — | 1 | 7.15 |
| CHEMBL4225514 | — | — | 1 | 7.14 |
| CHEMBL4228791 | — | — | 1 | 7.09 |
| CHEMBL4226876 | — | — | 1 | 7.03 |
| CHEMBL2403888 | — | — | 1 | 7.02 |
| CHEMBL4225301 | — | — | 1 | 6.80 |
| CHEMBL4228282 | — | — | 1 | 6.77 |
| CHEMBL4227401 | — | — | 1 | 6.77 |
| CHEMBL4227396 | — | — | 1 | 6.70 |
| CHEMBL4226979 | — | — | 1 | 6.58 |
| CHEMBL4225561 | — | — | 1 | 6.36 |
| CHEMBL4226548 | — | — | 1 | 6.28 |
| CHEMBL4225245 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4224849 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4226033 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4225009 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4227183 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4228440 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4229158 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL414993 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4225149 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4225051 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4224705 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4225768 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4229110 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4229052 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4225514 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4228791 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4226876 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2403888 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4225301 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4228282 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4227401 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4227396 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL4226979 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL4225561 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL4226548 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL4225245 | — | IC50 | = | 843.0 | nM | 6.07 |