Assay Detail
Functional
CHEMBL4223752
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Cytotoxicity against human etoposide-sensitive K562 cells after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.00 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4225504 | — | — | 1 | 6.33 |
| CHEMBL4226342 | — | — | 1 | 6.14 |
| CHEMBL3298730 | — | — | 1 | 6.07 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.91 |
| CHEMBL4225831 | — | — | 1 | 5.90 |
| CHEMBL221190 | DIPHYLLIN | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4225504 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4226342 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3298730 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4225831 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL221190 | DIPHYLLIN | IC50 | = | 2380.0 | nM | 5.62 |