Assay Detail
Functional
CHEMBL4223753
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Cytotoxicity against human K/VP.5 cells after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.76 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4225504 | — | — | 1 | 6.37 |
| CHEMBL4226342 | — | — | 1 | 6.16 |
| CHEMBL3298730 | — | — | 1 | 6.04 |
| CHEMBL4225831 | — | — | 1 | 5.89 |
| CHEMBL221190 | DIPHYLLIN | — | 1 | 5.64 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4225504 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4226342 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3298730 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4225831 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL221190 | DIPHYLLIN | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 35360.0 | nM | 4.45 |