Assay Detail
Binding
CHEMBL4224334
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Inhibition of ERK2 (unknown origin)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.54 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3645233 | — | — | 1 | 8.68 |
| CHEMBL3645231 | — | — | 1 | 8.32 |
| CHEMBL4225841 | — | — | 1 | 8.26 |
| CHEMBL4215228 | — | — | 1 | 8.25 |
| CHEMBL4225054 | — | — | 1 | 8.24 |
| CHEMBL3645235 | — | — | 1 | 8.15 |
| CHEMBL4226533 | — | — | 1 | 8.01 |
| CHEMBL4228552 | — | — | 1 | 7.92 |
| CHEMBL4229079 | — | — | 1 | 7.85 |
| CHEMBL4224792 | — | — | 1 | 7.81 |
| CHEMBL4228453 | — | — | 1 | 7.68 |
| CHEMBL4228816 | — | — | 1 | 7.62 |
| CHEMBL4228493 | — | — | 1 | 7.60 |
| CHEMBL3645228 | — | — | 1 | 7.39 |
| CHEMBL4225852 | — | — | 1 | 7.05 |
| CHEMBL4227512 | — | — | 1 | 6.94 |
| CHEMBL4228960 | — | — | 1 | 6.92 |
| CHEMBL4226108 | — | — | 1 | 6.24 |
| CHEMBL4225250 | — | — | 1 | 6.02 |
| CHEMBL4227869 | — | — | 1 | 5.88 |
| CHEMBL4224725 | — | — | 1 | - |
| CHEMBL4228559 | — | — | 1 | - |
| CHEMBL4227448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3645233 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3645231 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4225841 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4215228 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4225054 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3645235 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4226533 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4228552 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4229079 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4224792 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL4228453 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4228816 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4228493 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3645228 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4225852 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4227512 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4228960 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4226108 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL4225250 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4227869 | — | IC50 | = | 1311.0 | nM | 5.88 |
| CHEMBL4224725 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4228559 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4227448 | — | IC50 | > | 3000.0 | nM | - |