Assay Detail
Functional
CHEMBL4224366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human HT-29 cells harboring BRAF/KRAS mutant by caspase activation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.07 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3645231 | — | — | 1 | 7.10 |
| CHEMBL3645235 | — | — | 1 | 7.10 |
| CHEMBL3590107 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3645231 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3645235 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3590107 | — | IC50 | = | 96.0 | nM | 7.02 |