Assay Detail
Binding
CHEMBL4229694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human His-tagged MASP-2 (Cys300 to Phe686 residues) expressed in baculovirus infected insect cells using Z-Gly-Arg-S-Bzl as substrate preincubated with substrate for 10 mins followed by enzyme addition and measured for 15 mins
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Mannan-binding lectin serine protease 2 (CHEMBL4295646) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Chemical Approaches to Modulating Complement-Mediated Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 6.36 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4242095 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4242095 | — | Ki | = | 440.0 | nM | 6.36 |