Assay Detail
Functional
CHEMBL4229741
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at C5aR1 in human neutrophils assessed as inhibition of 0.1 nM recombinant human C5a-induced intracellular calcium release
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
C5a anaphylatoxin chemotactic receptor 1 (CHEMBL2373) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Chemical Approaches to Modulating Complement-Mediated Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1628668 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1628668 | — | IC50 | = | 2.0 | nM | 8.70 |