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Assay Detail

CHEMBL4229954

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]LSD from recombinant human 5-HT6R after 120 mins by scintillation counting method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 6 (CHEMBL3371)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
Zajdel P, Kos T, Marciniec K, Satała G, Canale V, Kamiński K, Hołuj M, Lenda T, Koralewski R, Bednarski M, Nowiński L, Wójcikowski J, Daniel WA, Nikiforuk A, Nalepa I, Chmielarz P, Kuśmierczyk J, Bojarski AJ, Popik P.
Eur J Med Chem (2018) 145 : 790 -804
PubMed 29407591 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.94 6.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4239823 1 6.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4239823 Ki = 116.0 nM 6.94