Assay Detail
Binding
CHEMBL4230002
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Inhibition of BRAF V600E mutant (unknown origin) after 20 mins by immunoblotting assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Effects of rigidity on the selectivity of protein kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.54 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3736320 | — | — | 1 | 8.40 |
| CHEMBL4248365 | — | — | 1 | 7.89 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 7.68 |
| CHEMBL4249028 | — | — | 1 | 7.62 |
| CHEMBL4242050 | — | — | 1 | 7.36 |
| CHEMBL4243230 | — | — | 1 | 7.34 |
| CHEMBL4237900 | — | — | 1 | 7.29 |
| CHEMBL4247506 | — | — | 1 | 7.19 |
| CHEMBL4250674 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3736320 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4248365 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4249028 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4242050 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4243230 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4237900 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4247506 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4250674 | — | IC50 | = | 87.0 | nM | 7.06 |