Assay Detail
Binding
CHEMBL4231192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human RET V804L mutant using peptide as substrate by fluorimetric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Proto-oncogene tyrosine-protein kinase receptor Ret (CHEMBL2041) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.59 | 4.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4238771 | — | — | 1 | 4.99 |
| CHEMBL1488812 | — | — | 1 | 4.18 |
| CHEMBL47173 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4238771 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1488812 | — | IC50 | = | 66200.0 | nM | 4.18 |
| CHEMBL47173 | — | IC50 | - | — | - |